Genesis Mission

The Genesis Mission: Transforming Science and Energy with AI

Genesis Mission is a national initiative to build the world's most powerful scientific platform to accelerate discovery science, strengthen national security, and drive energy innovation.

Quick Details For Applicants

Deadline is April 28th!

Most of the funding is being allocated for Phase 1 awards, which are relatively simple proposals to prepare.

  • 5 page narrative description

  • 9 month project period

  • budget cap at $750K

  • cost share may be required 

ORD has prepared a RESOURCE FOLDER with checklists, templates, and other handy info and we will soon have a webpage up with this and other info. 

Remember that this is a limited submission opportunity, but we have simplified the process due to the large number of focus areas. Instructions for limited approval have been emailed and are available in the folder linked above.

There are no citizenship requirements for applicants, but you must be affiliated with a university. There are also specific partnership requirements, so getting started soon is your best bet to lock your partners down. 

Challenge and Focus Areas

Genesis Mission will create a national discovery platform that unites the world’s most powerful supercomputers, AI systems, and emerging quantum technologies with the nation’s most advanced scientific instruments. Together, they form an integrated infrastructure for scientific exploration—an intelligent network capable of sensing, simulating, and understanding nature at every scale.

By connecting these systems, Genesis Mission will transform how science is done. It will generate a new class of high-fidelity data to train advanced AI models, empower researchers to solve the hardest scientific challenges, and accelerate discovery from years to months. In doing so, it will serve as both a national accelerator for innovation and a proving ground for the next generation of AI and quantum and robotics technologies.

To focus this immense computational power, the DOE has identified 21 specific Challenge Areas, each with multiple focus areas underneath. These challenge areas are designed to bridge the "valley of death" between laboratory discovery and commercial viability across three pillars of national importance.

To view a breakdown of the focus areas, go HERE. To view the original Department of Energy justification and implications document, go HERE. 

Challenge Area 1: Reenvisioning Advanced Manufacturing and Industrial Productivity

Challenge Area 2: Scaling the Biotechnology Revolution

Challenge Area 3: Securing America’s Critical Minerals Supply

Challenge Area 4: Delivering Nuclear Energy that is Faster, Safer, Cheaper

Challenge Area 5: Accelerating Delivery of Fusion Energy

Challenge Area 6: Transforming Nuclear Restoration and Revitalization

Challenge Area 7: Discovering Quantum Algorithms with AI

Challenge Area 8: Realizing Quantum Systems for Discovery

Challenge Area 9: Recentering Microelectronics in America

Challenge Area 10: Securing U.S. Leadership in Data Centers

Challenge Area 11: Achieving AI-Driven Autonomous Laboratories

Challenge Area 12: Designing Materials with Predictable Functionality

Challenge Area 13: Enhancing Particle Accelerators for Discovery

Challenge Area 14: Unifying Physics from Quarks to the Cosmos

Challenge Area 15: Predicting U.S. Water for Energy

Challenge Area 16: Scaling the Grid to Power the American Economy

Challenge Area 17: Unleashing Subsurface Strategic Energy Assets

Challenge Area 18: HPC Code Curation, Translation, and Development for Accelerated Scientific Discoveries

Challenge Area 19: AI For Scientific Reasoning

Challenge Area 20: Cybersecurity for AI-driven Science Workflows

Challenge Area 21: Artificial Intelligence in Fluid Flow for Energy Components and Technologies